Asthma is a disease causing difficulty in breathing, with recognizable symptoms: episodic wheezy breathlessness, which varies considerably within short periods of time, and is reversible (but not completely so in some patients) either spontaneously or with treatment.
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- Episodes of wheezy difficulty in breathing
- Narrowing of the air passages in the lungs and hence increased resistance to airflow.
The narrowing is due to different combinations of:
- contraction of muscles around the air passages
- swelling of the airway lining due to airway inflammation
- excessive mucus in the airways
- Rapid and considerable changes in airway obstruction (peak flow variation >= 20%)
- Frequent nocturnal episodes and low morning peak flow values
- Significant reversibility with drugs which resemble adrenaline, the beta2 agonists
- Significant reversibility with steroid drugs
- Symptom-free periods
- Frequent occurrence of allergy
- Inflammation of the air passages, characterized by eosinophils in the airway wall
- Bronchial hyper-responsiveness to nonspecific stimuli such as cold air or histamine
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